Yes, it's quite common to feel sick when using a MacBook in a car. Motion sickness arises when your body senses movement, but your eyes are focused on a non-moving screen, leading to a conflict between the visual and vestibular systems.
One way to ease the symptoms is to take frequent breaks and gaze out the window. Carsick.app also offers a solution by synchronizing your MacBook’s screen with the movement of the car, reducing the likelihood of feeling sick.