Yes, using a MacBook while traveling can cause nausea due to motion sickness. This occurs when your body senses the vehicle's movement, but your eyes are focused on the static screen, leading to conflicting sensory signals that can result in nausea.

One way to reduce this is by taking breaks and focusing on the horizon to stabilize your senses. Carsick.app is a helpful tool that syncs your MacBook’s visuals with the vehicle’s motion, reducing the sensory mismatch and preventing nausea.